PEDIATRICS Vol. 43 No. 1 January 1969, pp. 114-116
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The Effect of Phenobarbital on Diphenyihydantoin Metabolism in Children

Robert A. Buchanan M.D.1, John C. Heffelfinger M.D.2, and Charles F. Weiss M.D.3

1 Clinical Therapeutics Parke, Davis and Company 2800 Pigmouth Road Ann Arbor, Michigan 48106
2 Coldwater State Home and Training School Coldwater, Michigan
3 Clinical Therapeutics Parke, Davis and Company 2800 Plymouth Road Ann Arbor, Michigan 48106

Children appear to have a significantly accelerated rate of diphenyihydantoin metabolism after pre-treatment with phenobarbital.




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A. H. Conney and J. J. Burns
Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs
Science, November 10, 1972; 178(4061): 576 - 586.
[Abstract] [PDF]