PEDIATRICS Vol. 42 No. 6 December 1968, pp. 976-979
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THE IN VITRO RESPONSE OF HUMAN LYMPHOCYTES CHALLENGED BY RAGWEED ANTIGEN

Stuart H. Young M.D.1, Raymond E. P. Zimmerman M.D.1, and Elizabeth M. Smithwick M.D.1

1 Department of Pediatrics, Downstate Medical Center, Brooklyn, New York

More than 50% of human peripheral lymphocytes in culture will transform to a blastlike cell when incubated with phytohemagglutinin. To a lesser degree, the lymphocytes of a sensitive individual incubated with the appropriate antigen will also undergo blastogenesis. This phenomenon occurs not only in antigen-antibody systems associated with circulating antibody (e.g., tetanus) but also in those systems associated with delayed sensitivity (e.g., tuberculin). This study demonstrates that lymphocytes from a sensitive individual will also undergo blastogenesis when incubated with the appropriate antigen from the reagin group, in this case, ragweed antigen.

Submitted on December 29, 1967
Accepted on July 12, 1968