PEDIATRICS Vol. 42 No. 5 November 1968, pp. 833-837
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Selective Immunoglobulin A Deficiency and Intestinal Nodular Lymphoid Hyperplasia: Correction of Diarrhea with Antibiotics and Plasma

Joyce D. Gryboski M.D.1, Thomas W. Self M.D.1, Arthur Clemett M.D.1, and Teodoro Herskovic M.D.1

1 Departments of Pediatrics, Internal Medicine, and Radiology, Yale University School of Medicine and Yale-New Haven Hospital, 333 Cedar Street, New Haven, Connecticut 06510

A 13-year-old boy with chronic diarrhea and abdominal pain since 6 months of age, and recurrent fevers since 12% years of age, was found to have deficiency of IgA and nodular lymphoid hyperplasia of the small intestine. This disorder was similar to that of "dysgammaglobulinemia and intestinal lymphoid hyperplasia" described in adults in 1966. An associated giardiasis was eliminated by atabrine therapy and a malabsorption syndrome, cleared after treatment with tetracycline. Diarrhea and abdominal pain were not alleviated until he was treated with monthly fresh frozen plasma infusions.

It is to be emphasized that other forms of chronic diarrhea not related to immunoglobuun deficiencies do not respond to this type of therapy.




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