PEDIATRICS Vol. 42 No. 5 November 1968, pp. 828-833
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Non-immunologic Hydrops Fetalis Associated with a Large Hemangioendothelioma

Sara Jo Daniel M.D.1 and George Cassady M.D.2

1 Department of Pathology
2 Perinatal Research Laboratory, Department of Pediatrics, Newborn Division, University of Alabama Medical Center, 1919 7th Avenue South, Birmingham, Alabama 35233

Non-immunologic hydrops fetalis has been reported in association with such conditions as maternal diabetes mellitus, fetal infection, multiple fetal malformations (particularly cardiac), congenital nephrosis, homozygous alpha-thalassemia, prenatal closure of the foramen ovale, sublethal umbilical or chorionic vein thrombosis, and parabiotic syndrome.1-3 To our knowledge, the following case represents the first reported instance of fetal and placental hydrops associated with a tumor which acts as a fetal arteriovenous malformation.

A female infant was delivered to a 38-yearold Japanese woman at a calculated gestational age of 32 weeks. One previous pregnancy with the same Caucasian father had resulted in a living, normal child.




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G. P. Giacoia
Hydrops Fetalis (Fetal Edema): A Survey
Clinical Pediatrics, May 1, 1980; 19(5): 334 - 339.
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