PEDIATRICS Vol. 42 No. 5 November 1968, pp. 824-825
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Prolonged Symptomatic Neonatal Hypoglycemia Associated with Maternal Chlorpropamide Therapy

Preston Zucker M.D.1 and Gilbert Simon M.D.2

1 USAF, MC, Patrick Air Force Base, Florida 32935
2 College of Physicians and Surgeons, Columbia University, New York, New York 10032

Ordinarily, the hypoglycemia of infants of diabetic mothers is brief and asymptomatic.1 It is considered to result from fetal hyperinsulinism secondary to prenatal hyperglycemia. The infant described below had prolonged symptomatic hypoglycemia associated with maternal chlorpropamide (Diabinese) therapy.

Case Report

The patient, a 3,715 gm white male, was the product of a 37-week gestation of a gravida 3, para 2, A positive, 36-year-old mother by repeat cesarean section. The mother, a mild diabetic since age 31, had been receiving 250 mg chlorpropamide twice daily, including the morning of her delivery.

The infant's blood sugar was 20 mg/100 ml at 4 hours of age, and he was then transferred to Babies Hospital for further care.




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