PEDIATRICS Vol. 42 No. 4 October 1968, pp. 606-613
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INTRA-UTERINE HYPERPARATHYROIDISM SECONDARY TO MATERNAL HYPOPARATHYROIDISM

David Bronsky M.D.1, Rosario T. Kiamko M.D.1, Rogelio Moncada M.D.1, and Ira M. Rosenthal M.D.1

1 Departments of Endocrinology and Pediatric Radiology and the Hektoen Institute for Medical Research, Cook County Hospital; and the Departments of Medicine and Pediatrics, University of Illinois College of Medicine, Chicago

Two cases of intra-uterine hyperparathyroidism secondary to maternal hypoparathyroidism are recorded. The skeletal manifestations of hyperparathyroidism were present at birth in one infant but not in the other. Both mothers had a remission of clinical tetany during their pregnancy.

The infants' hyperparathyroidism may have been the result of hyperplasia of the fetal parathyroid glands in response to decreased placental transfer of calcium and fetal hypocalcemia. The relief of maternal tetany could have been accomplished either by passage of fetal parathyroid hormone or of calcium to the mother.

Submitted on November 27, 1967
Accepted on April 1, 1968




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[Abstract] [Full Text]