PEDIATRICS Vol. 42 No. 3 September 1968, pp. 501-504
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CYSTIC FIBROSIS AND DOWN'S SYNDROME

Aubrey Milunsky MB.B.Ch., M.R.C.P., D.C.H.1

1 Child Development Clinic, Department of Pediatrics (Boston Floating Hospital for Infants and Children), Tufts-New England Medical Center and The Tufts-University School of Medicine, Boston, Massachusetts

The association of cystic fibrosis and Down's syndrome has been documented for the first time in three cases. While the association may be considered as purely fortuitous, features common to both indicate a contrary possibility. Similar shared features include increased sodium content of parotid saliva, abnormal morphology of nailbed capillaries, autonomic dysfunction, an increased frequency of diabetes mellitus, and intestinal atresia.

Cystic fibrosis probably occurs more frequently in children with mongolism than heretofore suspected. A sweat test is mandatory in a child, albeit a mongol, having recurrent pneumonia.

Accepted on March 4, 1968




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 Arch. Dis. Child.Home page
C. KRUGER, H. BARMEIER, R. SAILER, and D. HARMS
Cystic fibrosis in Down's syndrome---diagnostic pitfalls and implications for the clinician
Arch. Dis. Child., February 1, 1998; 78(2): 194a - 194.
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