PEDIATRICS Vol. 42 No. 3 September 1968, pp. 483-491
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CEROID ACCUMULATION IN A PATIENT WITH PROGRESSIVE NEUROLOGICAL DISEASE

Arthur S. Levine M.D.1, Bernard Lemieux M.D.1, Richard Brunning M.D.1, James G. White M.D.1, Harvey L. Sharp M.D.1, Emanuel Stadlan M.D.1, and William Krivit M.D., Ph.D.1

1 Department of Pediatrics, Neurology, Laboratory Medicine, and Laboratory of Neuropathology, University of Minnesota School of Medicine, Minneapolis, Minnesota

After ceroid deposits were noted in a bone marrow aspirate, this patient's degenerative neurological disease was studied extensively. Ceroid, a highly oxidized lipid related to the universal "wear and tear" pigment of old age, was found in brain, renal, liver, spleen, and intestinal tissue. Because of this unique presentation of ceroid storage, the nature and cause were investigated.

Submitted on November 27, 1967
Accepted on April 9, 1968