PEDIATRICS Vol. 42 No. 2 August 1968, pp. 361-364
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Clinical Comparison of Pharmacologic Emetics in Children

Donald C. Corby MC1, Walter J. Decker MSC1, Martin J. Moran MC1, and Carl E. Payne M.T.(ASCP)1

1 Pediatric and Research Development Services, William Beaumont General Hospital, El Paso, Texas 79920

A simple method has been developed for the determination of the efficacy of pharmacologic emetic agents in children based on measuring the efficiency of stomach content return. The following conclusions can be reached from the study: (a) apomorphine can be safely administered by paramedical personnel, (b) it is not associated with significant CNS depression or protracted vomiting as has previously been feared, (c) it is faster acting than syrup of ipecac, and (d) it is equally effective in removing test material from the stomach as syrup of ipecac. However, it is apparent from this investigation that neither agent is truly effective or predictable in removing stomach contents, hence a search should be made for a more efficacious means of treating acute ingestions. Until more effective methods are found, it is recommended that syrup of ipecac be used as a first-aid measure in the home, and apomorphine be used in the emergency room.




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