PEDIATRICS Vol. 42 No. 2 August 1968, pp. 291-302
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THE USE OF ETHACRYNIC ACID IN INFANTS AND CHILDREN WITH CONGESTIVE HEART FAILURE

Albert W. Sparrow M.D.1, David Z. Friedberg M.D.1, and Alexander S. Nadas M.D.1

1 Department of Pediatrics, Harvard Medical School, and the Sharon Cardiovascular Unit of the Children's Hospital Medical Center, Boston

Administration of intravenous ethacrynic acid in doses of 1 mg/kg to 8 study patients and 14 "nonstudy" patients–all of whom had congestive heart failure–is reported. No significant changes in serum electrolytes are noted following administration of the drug. In nearly all cases, diureses and clinical improvement within a few hours after administration were noted. The authors suggest that intravenous ethacrynic acid replace mercurials in the treatment of acute congestive heart failure in infants and children.

Submitted on December 7, 1967
Accepted on February 9, 1968




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D. Z. Friedberg and S. B. Litwin
Cardiology Review : The Medical and Surgical Management of Patients with Congenital Heart Disease: A Survey of Current Knowledge and Practices
Clinical Pediatrics, April 1, 1976; 15(4): 324 - 333.
[Abstract] [PDF]