PEDIATRICS Vol. 41 No. 3 March 1968, pp. 636-639
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BENIGN RECURRENT CHOLESTASIS IN A CHILD

Harry Stark M.B., B.S., D.C.H., M.R.C.P.E.1

1 Department of Pediatrics B, "Rambam" Government Hospital, Haifa, Israel

A 17-month-old female patient developed signs of biliary obstruction, as evidenced by jaundice, pale stools, severe pruritus, bilirubinuria, and slightly elevated serum levels of cholesterol and alkaline phosphatase. These signs remitted spontaneously after 6 months. During the subsequent 5 years, the child suffered eight further such episodes, recurring at irregular intervals and lasting 1 to 6 months. During icteric episodes, BSP retention was increased and cholangiograms showed no biliary dye excretion. Laparotomy revealed no hepatic or biliary pathology.

Between periods of jaundice, all signs of biliary obstruction disappeared, BSP retention became normal and normal cholangiograms were obtained. Four liver biopsies, performed over 6 years, demonstrated marked cholestasis, with no distortion of the lobular pattern and no evidence of progressive histological changes.

The patient is believed to represent a further case of "benign recurrent cholestasis." In this condition, beginning in childhood or early adulthood, there is no evidence of progressive liver damage, despite numerous recurrences of biliary tract obstruction.

Submitted on December 13, 1966
Accepted on October 10, 1967




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S. Ozsoylu and N. Kocak
Benign Recurrent Intrahepatic Cholestasis
Clinical Pediatrics, February 1, 1971; 10(2): 123 - 125.
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