PEDIATRICS Vol. 41 No. 2 February 1968, pp. 531-533
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morgan, B. C.
Right arrow Articles by McGough, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morgan, B. C.
Right arrow Articles by McGough, G. A.

Failure to Achieve Oxygen Supplementation with Hydrogen Peroxide

Beverly C. Morgan M.D.1, Warren C. Guntheroth M.D.1, Donald Breazeale 1, and George A. McGough 1

1 Department of Pediatrics, University of Washington, School of Medicine, Seattle, Washington 98105

Hydrogen peroxide, administered rectally or intraperitoneally, has been reported to improve systemic oxygenation. Therefore, the effectiveness of intraperitoneal administration of hydrogen peroxide, 0.3%, was investigated in hypoxic rabbits as a possible method of supplementation of oxygenation in respiratory distress syndrome or in the postoperative cardiac patient. Although hydrogen peroxide initially caused a slight increase in arterial oxygen saturation, this increase was brief and was followed by a marked fall in arterial oxygen saturation. Hypotension occurred in all rabbits. It is suggested that the intraperitoneal administration of hydrogen peroxide for the purpose of extrapulmonary oxygenation is largely ineffective and hazardous, and it probably should not be attempted in the human subject.