PEDIATRICS Vol. 41 No. 2 February 1968, pp. 516-518
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RELAPSE FOLLOWING AMPICILLIN TREATMENT OF ACUTE HEMOPHILUS INFLUENZAE MENINGITIS

Lily M. Young M.D.1, James E. Haddow M.D.1, and Jerome O. Klein M.D.1

1 Pediatric Service and Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services of the Boston City Hopital; and the Department of Pediatrics, Boston University School of Medicine and Departments of Medicine and Pediatrics, Harvard Medical School

A case of meningitis due to Hemophilus influenzae in a 6-month-old child treated with ampicillin is presented. The child had a recurrence of bacteremia with orbital cellulitis 3 days after the conclusion of 14 days of parenteral treatment with 200 mg per kilogram per day. Although a substantial amount of clinical experience has already been presented as to the value of ampicillin in acute bacterial meningitis due to the common agents, careful observation of each patient for signs of lingering infection is still necessary.

This case represents a failure of ampicillin to eradicate H. influenzae infection.

Submitted on July 17, 1967
Accepted on August 21, 1967




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