PEDIATRICS Vol. 41 No. 2 February 1968, pp. 473-482
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RED CELL METABOLISM IN THE PREMATURE INFANT

III. Apparent Inappropriate Glucose Consumption for Cell Age

Frank A. Oski M.D.1, Charles Smith M.D.1, and Ernestine Brigandi 1

1 Department of Pediatrics, Hospital of the University of Pennsylvania and the University of Pennsylvania School of Medicine, Philadelphia

Erythrocyte glucose consumption was measured in the cells from premature and term in fants, adults, and subjects with reticulocytosis. Glucose consumption was related to red cell age as reflected in red cell G-6-PD and GOT activities. The erythrocytes of the premature infant appeared to consume less glucose than would be expected from their mean cell age.

Studies in reconstituted hemolysates indicated that the hexokinase reaction was the rate limiting step in cells from all groups and that glucose consumption could be markedly increased in newborn hemolysates by the addition of adenosine triphosphate. The presence of a different isoenzymatic form of hexokinase in cells of the neonate is discussed as one possible factor contributing to the difference in glycolytic rate.

Submitted on July 28, 1967
Accepted on September 18, 1967




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