PEDIATRICS Vol. 40 No. 6 December 1967, pp. 993-999
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NEGATIVE EFFECTS OF VITAMIN K PREPARATIONS ON GLUCURONYL TRANSFERASE ACTIVITY

Barbara Jones M.D.1

1 Department of Pediatrics, West Virginia University School of Medicine, Morgantown

In vitro studies using a mouse liver microsome system failed to demonstrate that menadiol sodium diphosphate, menadione sodium bisulfite, or phytonadione enhanced or inhibited the quantity of ortho-aminophenol glucuronide produced.

In vivo studies in young rats with these vitamin K analogues also failed to show an effect on glucuronide conjugation.

Based on this data, it is concluded that the hyperbilirubinemia seen in prematures after large doses of water-soluble vitamin K analogues is probably not due to an inhibitory effect of glucuronyl transferase. The evidence suggesting that it may be due in part to hemolysis is briefly reviewed.

Submitted on March 8, 1967
Accepted on July 17, 1967


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