PEDIATRICS Vol. 40 No. 6 December 1967, pp. 975-979
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DISSEMINATED PATHERGIC GRANULOMATOSIS IN A 4-MONTH-OLD INFANT: A CASE REPORT

Joseph O. Collins M.D.1, Harold A. Rosenberg M.D.1, and Philip Warren M.D.1

1 The Departments of Pediatrics and Pathology, Waterbury Hospital, Waterbury, Connecticut

A 4-month-old infant in whom sudden death terminated a clinical picture which included conjunctivitis but was dominated by high fever, leukocytosis, and clinical signs and x-ray evidence of pneumonitis is reported along with autopsy findings. The pathologic findings were dominated by a productive, exudative, and thrombotic occlusive vasculitis involving principally the coronary arteries and their branches with a lesser degree of vasculitis and granulomatous inflammation of lungs and spleen. The clinical picture may have given a clue to the underlying pathology. Fienberg's term, "pathergic granulomatosis," may be appropriately applied to cases of this type until more is known of the etiology.

Submitted on May 3, 1967
Accepted on July 10, 1967