PEDIATRICS Vol. 40 No. 6 December 1967, pp. 940-945
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ledbetter, M. K.
Right arrow Articles by Farhi, L. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ledbetter, M. K.
Right arrow Articles by Farhi, L. E.

READJUSTMENT IN DISTRIBUTION OF ALVEOLAR VENTILATION AND LUNG PERFUSION IN THE NEWBORN

Marion K. Ledbetter M.D.1, Takeshi Homma M.D.1, and Leon E. Farhi M.D.1

1 Departments of Physiology and Pediatrics, State University of New York at Buffalo, Buffalo, New York

An increased urinary-alveolar PN2 difference was demonstrated in normal, full-term infants during time first 6 days of life. This uADN2 results only from regions of the lungs with a low VA/Q and is not affected by true venous admixture, a diffusion barrier, or the presence of atelectasis. The mean aADN2 of 25 mm Hg on the first day of life was comparable to the N2 difference found in patients with severe emphysema. The mean PN2 difference decreased gradually and by time sixth day was approximately 10 mm.

The histologic signs of amniotic detritus in the lungs of virtually all new-born infants dying of non-respiratory causes on the first day of life and the subsequent lower incidence of these materials in the lungs of infants dying during the first week suggests the possibility of partial obstruction and low VA/Q in some regions of the lung. The temporary increase in uADN2, which was found in some cases may indicate that atelectatic areas may open at different times.

Submitted on July 5, 1967
Accepted on August 14, 1967




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
W. J. Warwick, L. G. Hansen, and H. Sharp
Absorption of Vitamin A in Patients with Cystic Fibrosis: Absorption Is Best with Emulsified Vitamin A Alcohol
Clinical Pediatrics, September 1, 1976; 15(9): 807 - 810.
[Abstract] [PDF]