PEDIATRICS Vol. 40 No. 6 December 1967, pp. 1063-1064
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Deafness, Hypothyroidism, and Pendred's Syndrome

GERALD J. BARGMAN M.D.1 and LYTT I. GARDNER M.D.2

1 Postdoctoral trainee, National Institute of Arthritis and Metabolic Diseases
2 Professor of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York 13210

The recent case report of MacGillivray, et al. in Pediatrics nicely demonstrates the relationship of neonatal hyperbilirubinemia and congenital hypothyroidism and also points out the association of congenital hypothyroidism with deafness. Their patient, in addition to being jaundiced, apparently did not respond to loud auditory stimulation when "maximally hypothyroid" at 1 month of age; but, at 6 months of age, "when the patient was euthyroid," no hearing deficit was thought to be present. While, as suggested by the authors, myxedematous changes in the mucosa of the eustachian tubes might account for what appeared to be a transient hearing loss, other factors should be considered.


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