PEDIATRICS Vol. 40 No. 4 October 1967, pp. 649-655
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JUVENILE OSTEOPOROSIS: REPORT OF A CASE INCLUDING A DESCRIPTION OF SOME METABOLIC AND MICRORADIOGRAPHIC STUDIES

Mark D. Cloutier M.D.1, Alvin B. Hayles M.D.1, B. Lawrence Riggs M.D.1, Jenifer Jowsey D.Phil.1, and William H. Bickel M.D.1

1 Mayo Clinic and Mayo Foundation: Sections of Pediatrics, Medicine, Surgical Research, and Orthopedic Surgery, and Mayo Graduate School of Medicine, Rochester, Minnesota

A case of idiopathic osteoporosis in a 12-year-old girl has been reported. Quantitative microradiographic studies of a biopsy specimen of iliac crest showed normal bone formation and an almost threefold increase in the level of bone resorption. The patient was observed without treatment, and a spontaneous clinical remission with roentgenographic improvement occurred. A second iliac crest biopsy specimen, obtained 15 months after the initial biopsy at a time when roentgenographic improvement was apparent, showed a return toward normal of the level of bone resorption. Metabolic balance studies conducted at this time showed that the patient was approximately in calcium balance. Because the majority of the previously reported cases have also exhibited spontaneous improvement, it is suggested that initially observation alone is indicated.

Submitted on January 30, 1967
Accepted on May 22, 1967