PEDIATRICS Vol. 40 No. 4 October 1967, pp. 627-635
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DERMAL ERYTHROPOIESIS IN NEONATAL INFANTS

A Manifestation of Intra-uterine Viral Disease

A. J. Brough M.D.1, D. Jones M.D.1, R. H. Page M.S.1, and I. Mizukami Ph.D.1

1 The Department of Pathology and Pediatrics, Children's Hospital of Michigan and Wayne State University School of Medicine and The Child Research Center of Michigan

Six cases of a unique transient dermatopathy occurring in neonatal infants and consisting of extramedullary dermal erythropoiesis are described. The process is transient. Three cases, on clinical, pathologic, and cultural grounds, were shown to be associated with viral infection due to cytomegalovirus. Two cases were presumed to be due to congenital rubella virus infection on clinicopathologic grounds. The sixth case was presumably associated with viral infection of unknown etiology. Embryologic and pathogenetic aspects of the cutaneous lesions are discussed.

Submitted on March 10, 1967
Accepted on May 18, 1967




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H. Z. Klein and M. Markarian
Dermal Erythropoiesis in Congenital Rubella: Description of an Infected Newborn Who Had Purpura Associated with Marked Extramedullary Erythropoiesis in the Skin and Elsewhere
Clinical Pediatrics, October 1, 1969; 8(10): 604 - 607.
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