PEDIATRICS Vol. 40 No. 4 October 1967, pp. 590-595
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ETIOLOGIC INTERRELATIONSHIP IN DOWN'S SYNDROME, HYPOTHYROIDISM, AND PRECOCIOUS SEXUAL DEVELOPMENT

H. F. Pabst M.D.1, S. Pueschel M.D.1, and D. A. Hillman M.D., Ph.D.1

1 The Department of Pediatrics, McGill University and The Montreal Children's Hospital, Montreal

This report describes results of endocrine and immunological investigations performed on an 8-year-old, hypothyroid, mongoloid girl with precocious puberty. Based on these studies, animal experiments, and a review of the pertinent literature, it is suggested that the observed hypothyroidism and Down's syndrome may both be related to thyroid autoimmunity, and the sexual precocity may be due to the response of the ovary to excessive TSH stimulation.

Submitted on January 5, 1967
Accepted on May 1, 1967