PEDIATRICS Vol. 40 No. 3 September 1967, pp. 444-446
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Immunological Response of the Newborn Infant to Coxsackie B-4 Infection

OTTO F. SIEBER JR. MC, USA1, ANDREW H. KILGUS MC, USA2, VINCENT A. FULGINITI M.D.3, and DAVID PEARLMAN M.D.3

1 Pediatric Service, Fitzsimons General Hospital and Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado
2 Department of Pediatrics, U. S. Army Hospital, U. S. Military Academy, West Point, New York
3 Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado

The sequence of antibody formation was followed from birth to 3 months of age in an infant who developed a mild neonatal Coxsackie B-4 virus infection. The infant produced specific 19-S Coxsackie B-4 neutralizing antibody by 14 days of age, with persistence of neutralizing activity in a 2 ME resistant fraction of immunoglobulin by 3 months of age.