PEDIATRICS Vol. 40 No. 3 September 1967, pp. 421-424
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THE INVOLVEMENT OF THE LABIAL MUCOUS SALIVARY GLAND IN PATIENTS WITH CYSTIC FIBROSIS. II. THE HETEROZYGOTE STATE

Laura R. Sweney M.S.1, Michael C. Hedrick D.D.S.1, Lawrence H. Meskin D.D.S., Ph.D.1, and Warren J. Warwick M.D.1

1 The Division of Preventive Dentistry, School of Dentistry; and Department of Pediatrics, College of Medical Sciences, University of Minnesota, Minneapolis

Eosinophilic plugs occur frequently in the acini of the labial mucous salivary glands of children with cystic fibrosis. Similar changes are rare in normal children or in siblings of patients with cystic fibrosis. These changes become frequent in adults. Although they appear earlier and more frequently, and significantly more severely in adults who are heterozygotic for cystic fibrosis, this criterion cannot be used to identify the heterozygote.

These observations suggest that factors are operating in patients with cystic fibrosis which affect certain tissues or their secretions in such a way that changes occur in childhood which would ordinarily not be seen until later in adult life.

Submitted on December 23, 1966
Accepted on May 13, 1967




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B. Shapiro, L. Lam, and L. Fast
Premature senescence in cultured skin fibroblasts from subjects with cystic fibrosis
Science, March 23, 1979; 203(4386): 1251 - 1253.
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