PEDIATRICS Vol. 40 No. 2 August 1967, pp. 233-246
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THE NEPHROTIC SYNDROME OF INFANCY: CLINICAL, MORPHOLOGIC, AND IMMUNOLOGIC STUDIES OF FOUR INFANTS

J. R. Hoyer M.D.1, A. F. Michael Jr. M.D.1, R. A. Good M.D., Ph.D.1, and R. L. Vernier M.D.1

1 The Department of Pediatrics and the Variety Club Heart Hospital Research Laboratories, University, of Minnesota

Two types of infantile nephrotic syndrome were studied in four patients. The disease in the first type was hereditary and congenital and showed characteristic renal morphology and resistance to corticosteroid therapy. In the second, the syndrome started at 6 months of age, showed no morphologic evidence of microcysts in the kidney, and was responsive to prolonged intravenous ACTH therapy. Immunologic investigation of three of these children included immunofluorescent studies of the kidneys, complement determinations, and skin grafts to their mothers. Evidence that immune factors are not primary in the pathogenesis of the nephrotic syndrome of infancy was obtained.

Submitted on January 3, 1967
Accepted on March 21, 1967