PEDIATRICS Vol. 40 No. 1 July 1967, pp. 92-95
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PEARSON, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PEARSON, H. A.

Studies of Granulopoiesis and Granulocyte Kinetics in Down's Syndrome

HOWARD A. PEARSON M.D.1

1 Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida

Normal mitotic and maturation granulocyte pools in Down's syndrome are evidenced by the finding of normal marrow cellularity and morphology. Normal marrow granulocyte reserves are indicated by a normal response to endotoxin injection. The normal levels of serum muramidase support the concept of a normal granulocyte turnover rate. Therefore, it is considered unlikely that there is a significant abnormality of granulocyte kinetics in Down's syndrome. It is also unlikely that increases in leukocvte enzymes in this condition are due to a relatively immature granulocyte population. Rather, they may reflect some general effect of genetic imbalance.




This article has been cited by other articles:


Home page
 PediatricsHome page
H. A. Pearson
The Ever-changing Content of Pediatrics Over Fifty Years
Pediatrics, July 1, 1998; 102(1): 168 - 176.
[Full Text]