PEDIATRICS Vol. 40 No. 1 July 1967, pp. 13-19
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brumley, G. W.
Right arrow Articles by Avery, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brumley, G. W.
Right arrow Articles by Avery, M. E.

LUNG PHOSPHOLIPIDS AND SURFACE TENSION CORRELATIONS IN INFANTS WITH AND WITHOUT HYALINE MEMBRANE DISEASE AND IN ADULTS

George W. Brumley M.D.1, W. Alan Hodson M.D.1, and Mary Ellen Avery M.D.1

1 The Harriet Lane Service, Department of Pediatrics, The Johns Hopkins Medical School, Baltimore, Maryland

Infants who have died with hyaline membrane disease have low concentrations of pulmonary phospholipids and reduced concentrations of saturated fatty acids at the alpha position of lung phosphatidyl choline. There is a highly significant correlation (p< .001) between levels below 12.6 mg of pulmonary phospholipid per gram wet weight lung and high minimum surface tension values of lung saline extracts.

Infants without hyaline membrane disease have high concentrations of pulmonary phospholipids (22.3 mg per gram wet weight). Infants who recovered from HMD and died of other causes show values intermediate to those of HMD and non-HMD infants. The excess above the critical minimum noted here suggests a reservoir of pulmonary surfactant.

Submitted on December 7, 1966
Accepted on April 6, 1967




This article has been cited by other articles:


Home page
 PediatricsHome page
A. H. Jobe
The Alveolar Lining Layer: A Review of Studies on Its Role in Pulmonary Mechanics and in the Pathogenesis of Atelectasis, by Mary Ellen Avery, MD, Pediatrics, 1962:30:324-330
Pediatrics, July 1, 1998; 102(1): 234 - 236.
[Abstract] [Full Text]

Home page
 ScienceHome page
P. M. Farrell and R. D. Zachman
Induction of Choline Phosphotransferase and Lecithin Synthesis in the Fetal Lung by Corticosteroids
Science, January 19, 1973; 179(4070): 297 - 298.
[Abstract] [PDF]