PEDIATRICS Vol. 4 No. 6 December 1949, pp. 723-729
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VARIABLE RESPONSE TO VITAMIN B12 OF MEGALOBLASTIC ANEMIA OF INFANCY

CALVIN W. WOODRUFF M.D.1, HOWARD W. RIPY M.D.1, J. CYRIL PETERSON M.D.1, and WILLIAM J. DARBY M.D., Ph.D.1

1 The Department of Pediatrics and the Division of Nutrition of the Departments of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

Two cases of megaloblastic anemia in infancy have improved following treatment with vitamin B12. A third case failed to respond to this factor but subsequently responded to pteroylglutamic acid (folic acid). It is suggested that megaloblastic anemia may be a syndrome which embraces more than one entity.

Submitted on February 8, 1949