PEDIATRICS Vol. 4 No. 6 December 1949, pp. 711-718
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HUMORAL ANTIBODY FORMATION IN INFANTS AGED ONE TO THREE MONTHS INJECTED WITH A TRIPLE (DIPHTHERIA-TETANUS-PERTUSSIS) ALUM-PRECIPITATED ANTIGEN

WILLIAM L. BRADFORD M.D.1, ELIZABETH DAY M.S.1, and FREDERICK MARTIN M.D.1

1 The Departments of Pediatrics and Bacteriology, University of Rochester School of Medicine and Dentistry, Rochester, N.Y.

Immunization of infants, 1 to 3 months of age, with an alum-precipitated antigen containing diphtheria and tetanus toxoids and Hemophilus pertussis organisms resulted in satisfactory humoral antibody levels against diphtheria and tetanus. Ninety-seven per cent of the subjects tested revealed more than the generally accepted level of protection against diphtheria and 94% showed a similar result against tetanus.

In regard to pertussis, only a few of the immunized infants developed agglutinative titers of 1:320 or higher. However, analysis of the titers in terms of the expected number of cases of pertussis, if subjected to family exposure, indicates that probably 75% of the infants were protected.

When tested six months after the completion of the original series of injections, each of 29 infants gave positive skin reactions to the injection of agglutinogen.

Submitted on February 21, 1949




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