PEDIATRICS Vol. 4 No. 1 July 1949, pp. 9-15
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A NEW REPOSITORY PENICILLIN (A FORM OF AQUEOUS PENICILLIN G PROCAINE) IN INFANTS AND CHILDREN

HORACE M. GEZON M.D.1, DUKE CHO CHOY M.D.1, DAVID T. HELLYER M.D.1, WILLIAM H. SMITH M.D.1, and FRED L. STRICKER M.D.1

1 The Bobs Roberts Memorial Hospital for Children and the Department of Pediatrics, University of Chicago, Chicago, Ill.

Eighty-two children with a variety of infectious diseases were treated with a daily injection of a new repository penicillin, aqueous penicillin G procaine (Abbott).

Clinical success was obtained in 68 of 75 patients. In one, the results were considered fair, in three poor, and in three unknown.

Thirty-five patients had a beta Str. hemolyticus, and 10 a pneumococcus isolated from the nose or throat. Bacteriologic success was obtained in all streptococcal infections, but in only 6 of 10 pneumococcal infections.

All of the streptococci were sensitive to penicillin when tested by in vitro methods.

Penicillin serum levels with a mean maximum of approximately 2 u./ml. were observed at two hours, and mean minimum of approximately 0.063 u./ml. at 24 hours. The curve of intermediate values approximated a normal curve.

Submitted on October 13, 1948