PEDIATRICS Vol. 39 No. 6 June 1967, pp. 884-890
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HYPERTENSION AND HYPOKALEMIC ALKALOSIS ASSOCIATED WITH UNDERPRODUCTION OF ALDOSTERONE

Dagfinn Aarskog M.D.1, Karl F. Støa Ph.D.1, Thor Thorsen B.Sc.1, and Karl W. Wefring M.D.1

1 University of Bergen, School of Medicine, Department of Paediatrics and the Hormone Laboratory, Bergen, Norway

A 10-year-old girl presented with a syndrome characterized by hypertension, hypokalemic alkalosis, and inability of the kidneys to concentrate the urine and conserve potassium. The aldosterone excretion and secretion rate were subnormal to low both when she was on a liberal sodium intake and on restricted sodium intake. Treatment with Triamterene resulted in potassium retention , restoration of normal serum potassium level, abolition of the alkalosis, normalization of the blood pressure, and increase of aldosterone secretion rate. The differential diagnosis in conditions associated with hypokalemic alkalosis and renal wastage of potassium is discussed.

Submitted on October 28, 1966
Accepted on December 27, 1966