PEDIATRICS Vol. 39 No. 6 June 1967, pp. 876-883
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SERUM ALBUMIN RESERVE PSP DYE BINDING CAPACITY IN INFANTS WITH KERNICTERUS

J. F. Lucey M.D.1, T. Valaes M.D.1, and S. A. Doxiadis M.D.1

1 The Queen Anna-Maria Institute of Child Health, Athens, Greece and the Department of Pediatrics, University of Vermont College of Medicine, Burlington, Vermont

Observations have been reported on the serum albumin PSP reserve dye binding capacity in a group of 93 newborn infants with total serum bilirubin concentrations ranging between 20 to 52 mg/100 ml. Eleven of these infants had a clinically established diagnosis of kernicterus at the time of these measurements. The PSP reserve dye binding capacity in these neurologically damaged infants was not different from that found in clinically normal infants with the same degree of jaundice. We, therefore, do not believe that this test is sufficiently sensitive to serve as a useful adjunct in assaying the risk of neurologic damage at a particular serum concentration of bilirubin.

Submitted on September 28, 1966
Accepted on January 23, 1967