PEDIATRICS Vol. 39 No. 5 May 1967, pp. 780-782
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Hypertension and Seizures Following Methyldopa Infusion

WILLIAM FELDMAN M.D., C.M., F.R.C.P.(C)1, DONALD HILLMAN M.D., Ph.D.2, TADLAH BALIAH M.D.2, and KEITH N. DRUMMOND M.D., C.M., F.R.C.P.(C)2

1 Medical Research Council of Canada Renal Fellow
2 The Renal Laboratory, McGill University-Montreal Children's Hospital Research Institute, Montreal 25, Canada

A 6-year-old girl with hypertension secondary to chronic glomerulonephritis was given two infusions of methyldopa in an attempt to lower the blood pressure. A paradoxical hypertensive response occurred both times; after the second infusion seizures developed. It is felt that this untoward response indicates the need for caution when methyldopa is given intravenously.