1 Department of Pathology, The University of Vermont College of Medicine, Burlington, Vermont, and Congenital Heart Disease Research and Training Center, Chicago, Illinois
A quantitative study was undertaken of body size, organ size, and cellular structure in 220 individuals dying with congenital heart disease. Infants dying in the perinatal period had evidences of a mild intra-uterine growth retardation. Infants 1 month to 8 years of age had organ and cellular abnormalities closely resembling those usually found with chronic undernutrition. Older individuals dying with congenital cardiac malformations had organ and cellular abnormalities which may be related to chronic hypoxia.
Submitted on June 23, 1966