PEDIATRICS Vol. 39 No. 2 February 1967, pp. 252-257
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URINARY CATECHOLAMINE EXCRETION BY HEALTHY CHILDREN

I. Daily Excretion of Dopamine, Norepinephrine, Epinephrine, and 3-Methoxy-4-Hydroxymandelic Acid

Mary L. Voorhess M.D.1

1 Children's Clinical Research Center and Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York

There is increase in the daily urinary excretion of dopamine (DA), norepinephrine (NE), epinephrine (E), and 3-methoxy-4-hydroxymandelic acid (VMA) with age. The mean output in micrograms per 24 hours for various age groups is as follows: birth to 1 year-DA 60.9 (± 24.3), NE 10.6 (± 3.4), E 1.3 (± 1.2), VMA 569 (± 309); 1 through 5 years—DA 124.1 (± 40.7), NE (18.8 ± 7.0), E 3.2 (± 2.7), VMA 1348 (± 433); 6 through 15 years—DA 169.3 (± 72.6), NE 37.4 (± 16.6), E 4.8 (± 2.4), VMA 2373 (± 698); over 15 years—DA 249.1 (± 74.9), NE 50.7 (± 15.7), E 7.1 (± 3.3), VMA 3192 (± 699).

The studies suggest that the daily output of these compounds in the various age groups is similar when related to body surface area after infancy.

Submitted on June 20, 1966
Accepted on August 29, 1966




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E. Silbergeld and J. Chisolm Jr
Lead poisoning: altered urinary catecholamine metabolites as indicators of intoxication in mice and children
Science, April 9, 1976; 192(4235): 153 - 155.
[Abstract] [PDF]