PEDIATRICS Vol. 39 No. 1 January 1967, pp. 75-81
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HYALINE-MEMBRANE FORMATION AND PULMONARY PLASMINOGEN-ACTIVATOR ACTIVITY IN VARIOUS STRAINS OF MICE

Jack Lieberman M.D.1 and Frederick Kellogg M.D.2

1 The Department of Medicine, Veterans Administration Hospital, Long Beach
2 The UCLA School of Medicine, Los Angeles, California

Various strains of mice were found to differ in the frequency with which they developed pulmonary hyaline-membranes in response to breathing 90% oxygen. Of 13 strains tested, Swiss-Albino and C3H/HEJ strains developed hyaline membranes most readily, and AKR and MA/J strains were most resistant. No difference in plasminogen-activator content of lung tissue could be detected between these strains of mice. The formation of pulmonary hyaline membranes did not seem to affect the survival time of mice in oxygen, but membranes were found most consistently in animals that had been in oxygen for 100 hours or more. An elevation of environmental temperature to 32°C hastened the death of the mice in oxygen but also reduced the incidence of hyaline-membrane formation. The use of suitable strains of mice is recommended as an experimental model for pulmonary hyaline-membrane formation.

Submitted on April 11, 1966
Accepted on July 29, 1966