PEDIATRICS Vol. 39 No. 1 January 1967, pp. 145
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Possible Oral-Facial-Digital Syndrome in a Surviving Male

WONG HOCK BOON MB, FRCPE, FREPS, DCH1

1 Department of Paediatrics, University of Singapore, General Hospital, Singapore 3

In the May issue of Pediatrics (37:812, 1966), Dr. Jacob Wahrman and his colleagues reported a male child with the oral-facial-digital syndrome whose chromosome karyotype revealed that in actual fact he was also an example of a Klinefelter's Syndrome 47 (XXY). Since the majority of these cases have been female, the authors reviewed previous published male cases and came to the conclusion that the gene for the OFD Syndrome would be lethal in a male with a normal male chromosome karyotype.