PEDIATRICS Vol. 38 No. 5 November 1966, pp. 874-878
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GASTRIC RESPONSE TO SPECIFIC DISEASE IN INFANTS

Gordon B. Avery M.D., Ph.D.1, Judson G. Randolph M.D.1, and Thomas Weaver B.A.1

1 The Newborn and Surgical Services of The Children's Hospital of the District of Columbia, and the Schools of Medicine, Georgetown and George Washington Universities

1. A method of gastric analysis has been developed for the study of newborn infants. Results obtained with this method have shown it to reflect more accurately the ongoing secretory activity of the stomach. Previous methods of sampling left significant and varying amounts of acidity behind in the stomach rendering much of the available data inconclusive.

2. For the first time, gastric function has been correlated with specific disease states in the infant.

3. The volume, pH, total acidity, chloride content, and pepsin activity have been found to vary independently of one another.

4. Pneumonia and bronchiolitis, two conditions producing compromised respiratory function, were characterized by decreased total acidity, a more alkaline pH, and decreased pepsin activity.

5. Infants with short gut after bowel resection displayed highly significant increases in total gastric acidity and rate of acid formation, and a lower gastric pH.

6. Infants with acyanotic congenital heart disease showed significantly decreased pepsin content and increased chloride concentration despite normal acidity. Conversely, the few infants with cyanotic congenital heart disease studied had decreased volume of gastric juice and rate of acid formation.

Submitted on December 2, 1965
Accepted on July 1, 1966




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[Abstract] [PDF]