PEDIATRICS Vol. 38 No. 2 August 1966, pp. 207-210
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THE PROTECTIVE EFFECT OF POLYVALENT OIL-ADJUVANT INFLUENZA VACCINE IN CHILDREN

J. J. Quilligan Jr. M.D.1 and H. D. Baernstein Jr. M.D.1

1 Loma Linda University School of Medicine, Departments of Pediatrics and Pathology, and Virus Laboratory, Los Angeles County General Hospital, Los Angeles, California

Polyvalent oil-adjuvant influenza vaccine has been shown to be practical and effective in children. Its use resulted in respectable levels of antibody after 2 and 3 years when two injections were given. A protection ratio of 3.1 was observed during natural challenge with A2 virus after 2frac12 years. The value of a program of surveillance for the presence of viral respiratory disease in a hospital population offers the opportunity to test vaccine efficacy under conditions of natural challenge.

Submitted on August 16, 1965
Accepted on March 1, 1966