PEDIATRICS Vol. 38 No. 1 July 1966, pp. 102-110
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STUDIES IN ACUTE IRON POISONING:

II. Further Observations on Desferrioxamine in the Treatment of Acute Experimental Iron Poisoning

Charles F. Whitten M.D.1, You-chen Chen M.D.1, and George W. Gibson M.S.1

1 Department of Pediatrics of Wayne State University and Children's Hospital of Michigan, Detroit

Up to 50% of acutely iron-poisoned dogs survived when treated with various dosages of intravenous and intestinal desferrioxamine and supportive therapy. These results support the current optimism relative to the value of this drug in the treatment of acute iron poisoning in children.

The results of the use of adjuvants with intestinal and intravenous desferrioxamine were not encouraging. Corticosteroids and hemodialysis did not improve the survival rate and levarterenol worsened it.

It was confirmed that the iron desferrioxamine complex is absorbed and that both desferrioxamine and ferrioxamine can exhibit toxicity.

Submitted on December 20, 1965
Accepted on January 29, 1966




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