PEDIATRICS Vol. 37 No. 6 June 1966, pp. 1030
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Editor's Note: Doctors Falek, Schmidt and Jervis commented as follows:

Rina Schmidt M.D.1, George A. Jervls M.D.2, and Atrhur Falek Ph.D.3

1 Department of Meical Genetics New York State Psychiatric Institute, Columbia University
2 Research Department, Letchworth Village
3 Division Human Genetics, Georgia Mental Health Institute, Emory University

We should like to thank Drs. Opitz and Smith for their detailed commentary on our report of chromosome anomalies in a large pedigree with de Lange syndrome. It is certainly most kind of them to postulate that our patients represent a new multiple anomaly. However, whether or not all cases of de Lange syndrome have a common etiology is at present unknown, and it would be most presumptuous of us to assume that our cases compose an entirely new disorder.