PEDIATRICS Vol. 37 No. 4 April 1966, pp. 577-582
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CHEMICAL THERMOGENESIS IN NEWBORN INFANTS: CATECHOLAMINE EXCRETION AND THE PLASMA NON-ESTERIFIED FATTY ACID RESPONSE TO COLD EXPOSURE

David Schiff M.D.1, Leo Stern M.D.1, and Jean Leduc M.D.1

1 Department of Pediatrics, McGill University; The Medical Service of the Montreal Children's Hospital, and the Department of Physiology, University of Montreal

Exposure to a cold environment resulted in a simultaneous increase in urinary noradrenalin excretion and plasma non-esterified fatty acid levels in eight newborn infants. A similar, though less constant, infants crease occurred in the excretion of urinary dopamine. The infusion of noradrenalin into two infants resulted in a rapid rise of plasma NEFA and a sustained increase in rectal temperature. It is proposed that the increase in plasma NEFA on exposure to cold represents an intermediary step in the role of noradrenalin as the mediator of chemical thermogenesis in the newborn infant.

Submitted on August 10, 1965
Accepted on October 29, 1965


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