PEDIATRICS Vol. 37 No. 4 April 1966, pp. 556-564
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CHEMORECEPTOR REFLEXES IN THE NEWBORN INFANT: EFFECT OF COOLING ON THE RESPONSE TO HYPOXIA

Eliana Ceruti M.D.1

1 Cardiovascular Research Institute, University of California, San Francisco Medical Center, San Francisco, California

1. The effect of brief exposures to warm and cool environments on the newborn infant's response to hypoxia was studied in 14 healthy full-term infants.

2. In all infants studied in a cool environment minute ventilation was significantly higher while breathing 21% O2.

3. During the first week of life, hypoxia (12% O2) induced a transient hyperventilation in babies studied in a warm environment. This response was not seen when the infants were in a cool environment.

The ventilatory response was the same even when the PACOACO2 was maintained constant and elevated.

A decrease in ventilation and return to control levels after 21% O2 was reinstituted, occurred at both thermal environments.

4. PACOACO2 decreased during hypoxia, at both ambient temperatures.

5. Heart rate increased significantly during hypoxia and was not affected by the environmental temperature or age.

6. The ventilatory response to 3% CO2 inhalation was unaffected by temperature or age.

7. After the first week of life, a sustained hyperventilation during hypoxia occurred at both ambient temperatures.

Submitted on June 16, 1965
Accepted on October 11, 1965




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