PEDIATRICS Vol. 37 No. 3 March 1966, pp. 529-530
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Beta-1C-Globulin in Glomerular Nephritis

MARTIN R. KLEMPERER M.D.1, SAMUEL P. GOTOFF M.D.1, CHESTER A. ALPER M.D.1, and FRED S. ROSEN M.D.1

1 Department of Pediatrics, Harvard Medical School, Laboratory of Immunology, 300 Longwood Avenue, Boston, Massachusetts 02115

It was previously reported that hemolytic activity was restored to the serum of an individual with acute glomerulonephritis upon the addition of purified beta-1C-globulin (Cacute3). At the time it was known that this preparation of beta-1C-globulin was contaminated with two other complement components, beta-1F-globulin (Cacute5) and Cacute62 though the latter complement component has not been immunochemically characterized. Recently a method has been described by Nilsson and Müller-Eberhard for the separation of these proteins, so that immunochemically pure beta-1C-globulin can be obtained which is free of beta-1F-globulin, Cacute6 and beta-1H-globulin, another contaminant which is not a complement component.




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C. A. Alper, A. S. Levin, and F. S. Rosen
Beta-1C-Globulin: Metabolism in Glomerulonephritis
Science, July 8, 1966; 153(3732): 180 - 182.
[Abstract] [PDF]