PEDIATRICS Vol. 37 No. 3 March 1966, pp. 447-455
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THE USE AND MODE OF ACTION OF ETHACRYNIC ACID IN NEPHROGENIC DIABETES INSIPIDUS

David M. Brown M.D.1, John W. Reynolds M.D.1, Alfred F. Michael M.D.1, and Robert A. Ulstrom M.D.1

1 Department of Pediatrics, University of Minnesota, and Department of Pediatrics, University of California, Los Angeles

The use of diuretic agents in the treatment of nephrogenic diabetes insipidus had been reported to result in decreased urine volume and decreased clearance of free water. A study of the use of ethacrynic acid, a potent saluretic agent, was instituted in patients with nephrogenic diabetes insipidus in an attempt to achieve a significant antidiuretic response while allowing a liberal sodium diet. Intravenous ethacrynic acid resulted in decreased urine volume, decreased clearance of free water and decreased RPF and GFR. Prolonged oral administration of ethacrynic acid promoted a significant antidiuretic response when the daily sodium intake was limited to 60 mEq. The effect of ethacrynic acid on renal function, potassium and chloride. excretion, and uric acid metabolism are discussed.

Submitted on July 9, 1965
Accepted on September 1, 1965