PEDIATRICS Vol. 37 No. 1 January 1966, pp. 7-18
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STUDY OF VIRAL ANTIBODIES BY THE PAPER-RADIOACTIVE VIRUS METHOD

Horace L. Hodes M.D.1, Ruth Berger M.D.1, Eugene Ainbender M.D.1, Helen D. Zepp A.B.1, and Maria M. Hevizy Ph.M.1

1 Department of Pediatrics, The Mount Sinai Hospital, New York

1. A filter paper-radioactive virus method for the detection and study of viral antibodies in human serum is described. The method gives accurate and reproducible results. It is particularly suitable for antibody testing on a mass basis. A slight modification makes the method more sensitive than standard tissue culture neutralization tests.

2. The major poliovirus antibody in human serum combines with the virus to form a particle which is non-infectious and of low mobility.

Submitted on March 3, 1965
Accepted on May 28, 1965