PEDIATRICS Vol. 37 No. 1 January 1966, pp. 34-42
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CORTISOL PRODUCTION RATE

II. Normal Infants, Children, and Adults

Frederic M. Kenny M.D.1, Chawalit Preeyasombat M.D.1, and Claude J. Migeon M.D.1

1 University of Pittsburgh School of Medicine and the Children's Hospital of Pittsburgh; and the Harriet Lane Service of the Children's Medical and Surgical Center, Johns Hopkins Hospital and University

Newborn infants less than five days of age secrete more cortisol per meter square of body surface area than do older infants, children, and adults. However, their urinary 17-hydroxycorticosteroids corrected for surface area are lower than those of infants 5-20 days of age. The difference between the data on cortisol production and urinary excretion is accounted for by the utilization of different pathways for metabolic disposal of cortisol. Between birth and age 5 days, vaginally delivered and cesarean section babies produce similar amounts of cortisol (18.7 ± 3.7 and 17.2 ± 5.8 mg/M2/24 hr, respectively).

When corrected for body surface area, the CPR of 20 subjects 4 months to 20 years of age and of 28 subjects 21 to 48 years of age fell in a similar range, the mean and standard deviation for the 48 individuals being 11.8 ± 2.5 mg/M2/24 hr.

Submitted on April 12, 1965
Accepted on August 2, 1965




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