PEDIATRICS Vol. 37 No. 1 January 1966, pp. 26-33
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VAGINAL BLEEDING IN GONADAL DYSGENESIS

Stephen Kaufman M.D.1

1 Department of Pediatrics, University of California-San Francisco Medical Center, San Francisco, California

Two cases of ovarian dysgenesis with periodic vaginal bleeding are presented, with evidence which suggests chromosomal mosaicism. In a review of the world literature our cases are the fourteenth and fifteenth described with vaginal bleeding and chromosomal analysis. Our first case also demonstrates the foreshortened metacarpals of pseudo- and pseudopseudohypoparathyroidism. It is the fourth case reported with ovarian dysgenesis and brachymetacarpal dwarfism and the first in which renal tubular sensitivity to parathyroid hormone has been determined. It is suggested that the clinical term, Turner's syndrome, be replaced by a classification based on chromosomal karyotype.

Submitted on February 3, 1965
Accepted on March 29, 1965