PEDIATRICS Vol. 36 No. 6 December 1965, pp. 911-921
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QUANTITATIVE ASSAY OF DISACCHARIDASE ACTIVITIES OF SMALL INTESTINAL MUCOSAL BIOPSY SPECIMENS IN INFANCY AND CHILDHOOD

R. R.W. Townley M.B., B.S. (Melb.)1, K. T. Khaw M.D.1, and H. Shwachman M.D.1

1 Department of Medicine and the Division of Laboratories and Research, The Children's Hospital Medical Center and Department of Pediatrics, Harvard Medical School

The disaccharidase activities of small bowel biopsy specimens obtained from 34 infants and children with various disorders were measured quantitatively. One example of a primary disaccharidase deficiency and several of a secondary type were encountered. The advantages of quantitative measurements in the recognition of these two groups are discussed. Small bowel biopsy, even in small infants, is felt to be a safe procedure, with considerable potential for study of many other metabolic aspects of intestinal mucosal function.

Submitted on January 20, 1965
Accepted on May 12, 1965




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