PEDIATRICS Vol. 36 No. 6 December 1965, pp. 905-910
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COMPARISON OF THE TOLERANCES OF ANESTHETIZED ADULT DOGS AND PUPS TO KCI INFUSION

Paul M. Taylor M.D.1, Harold B. Seder B.S.1, James Mering B.S.1, and Doris W. Watson B.S.1

1 Department of Pediatrics, University of Pittsburgh Medical School and The Alan Magee Scaife Laboratories of the Magee-Women's Hospital, Pittsburgh, Pennsylvania

The hypothesis that pups might tolerate hyperpotassemia better than adult dogs was tested. Adult dogs and newborn pups (2 hours to 4 days old), anesthetized with pentobarbital sodium, were infused with 1.0% KCl solution at the rate of 0.5 ml/kg/min until death. Criteria for tolerance to hyperpotassemia were survival time, plasma K concentration at loss of P wave on ECG, and plasma K concentration at death. Spontaneously breathing adult dogs and pups did not differ significantly in any of these criteria. Both adult dogs and pups developed metabolic acidosis during KCl infusion. The adult dogs hyperventilated, appropriately, during KCl infusion, but the pups hypoventilated and became hypoxemic and hypercapneic. Maintaining pups at near-normal arterial pH during KCl infusion by artificial hyperventilation did not improve their tolerance to hyperpotassemia.

Submitted on February 4, 1965
Accepted on June 7, 1965




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