1 University of Singapore Faculty of Medicine, Departments of Pediatrics and Biochemistry, and University of California International Center for Medical Research and Training (San Francisco-Singapore)
In full-term Chinese, Malay, and Indian infants of Singapore neonatal hyperbilirubinemia generally is more severe and of longer duration than in Singapore-born British infants. The ethnic group differences in neonatal bilirubin levels might be the expression of previously unrecognized genetic differences in bilirubin metabolism, although the importance of some environmental factors is not completely understood. The ordinary definitions of "physiologic" jaundice, which have evolved principally from observations in Western countries, are not appropriate to Singapore-born Asian infants and may not be appropriate to infants in many parts of the world. Further geographic studies of neonatal bilirubinemia are indicated.
Submitted on December 10, 1964
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